Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Safety of medical male circumcision in human immunodeficiency virus-infected men in Rakai, Uganda

TitleSafety of medical male circumcision in human immunodeficiency virus-infected men in Rakai, Uganda
Publication TypeJournal Article
Year of Publication2014
AuthorsKigozi, G, Musoke, R, Kighoma, N, Kiwanuka, N, Makumbi, F, Nalugoda, F, Wabwire-Mangen, F, Serwadda, D, Wawer, MJ, Gray, RH
Date PublishedFeb
ISBN Number0090-4295
Accession Number24286598
Keywords*HIV Infections, Adult, Circumcision, Male/*adverse effects, Humans, Male, Patient Safety, Prospective Studies, Sexual and Reproductive Health, Uganda

OBJECTIVE: To assess the safety of medical male circumcision (MMC) among human immunodeficiency virus (HIV)-infected men with CD4 levels <350 cells/mm(3), CD4 counts >/= 350 cells/mm(3), and HIV-negative men. METHODS: Two hundred forty-two HIV-infected men and a sample of 262 HIV-negative consenting men aged 12 years or older who requested free MMC were enrolled in a prospective study. Blood for HIV testing and a CD4 count were collected before surgery. During weekly follow-up over 6 weeks, data were collected on wound healing and adverse events (AEs) by examination, and resumption of sex and condom use ascertained by interview. Surgery-related AEs were characterized by type, severity, management, and resolution. Chi-square and Fisher's exact tests were used to test for differences in AE proportions. RESULTS: Overall, only 2 of the 453 men experienced moderate AEs, a rate of 0.44 per 100 surgeries. No AE occurred among HIV-negative men, whereas the AE rate among HIV-infected men with CD4 counts >/= 350 cells/mm(3) was 0.79 per 100 surgeries, and among men with CD4 counts <350 cells/mm(3) the rate was 1.19 per 100 surgeries (P = .214). AE rates were comparable for all characteristics (P >.05). CONCLUSION: HIV-positive men can be safely included in MMC roll out programs without necessitating presurgery CD4 counts determination.