Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda

TitleHerpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda
Publication TypeJournal Article
Year of Publication2015
AuthorsGrabowski, MK, Kigozi, G, Gray, RH, Armour, B, Manucci, J, Serwadda, D, Redd, AD, Nalugoda, F, Patel, EU, Wawer, MJ, Quinn, TC, Tobian, AA
JournalJ Infect Dis
Date PublishedNov 15
ISBN Number1537-6613 (Electronic)0022-1899 (Linking)
Accession Number25943201
Keywords*Circumcision, Male, *Virus Shedding, Adolescent, Adult, Disease Transmission, Infectious/prevention & control, Herpes Genitalis/epidemiology/*virology, herpes simplex virus type 2 (HSV-2), Herpesvirus 2, Human/*isolation & purification, HIV Infections/complications, human immunodeficiency virus (HIV), Humans, Male, male circumcision, penile viral shedding, Prevalence, Prospective Studies, Risk Assessment, Uganda, Viral Load, Wounds and Injuries/*virology, Young Adult

A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.