Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Geographic HIV type 1 subtype distribution in Rakai district, Uganda

TitleGeographic HIV type 1 subtype distribution in Rakai district, Uganda
Publication TypeJournal Article
Year of Publication2009
AuthorsCollinson-Streng, AN, Redd, AD, Sewankambo, NK, Serwadda, D, Rezapour, M, Lamers, SL, Gray, RH, Wawer, MJ, Quinn, TC, Laeyendecker, O
JournalAIDS Research and Human Retroviruses
Date PublishedOct
ISBN Number1931-8405; 0889-2229
Accession Number19803713
KeywordsAdolescent, Adult, Animals, Female, gag Gene Products, Human Immunodeficiency Virus/genetics, Genotype, Geography, HIV Envelope Protein gp41/genetics, HIV Infections/epidemiology/virology, HIV-1/classification/genetics/isolation & purification, Humans, Male, Middle Aged, Molecular Sequence Data, Rural Population, Sequence Analysis, DNA, Uganda/epidemiology, Young Adult

To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design.