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Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda

TitleVaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda
Publication TypeJournal Article
Year of Publication2015
AuthorsGianella, S, Redd, AD, Grabowski, MK, Tobian, AA, Serwadda, D, Newell, K, Patel, EU, Kalibbala, S, Ssebbowa, P, Gray, RH, Quinn, TC, Reynolds, SJ
JournalJ Infect Dis
Volume212
Pagination899-903
Date PublishedMar 5
ISBN Number1537-6613 (Electronic)0022-1899 (Linking)
Accession Number25743428
Keywordsacyclovir, antiretroviral therapy (ART), cytomegalovirus (CMV), human immunodeficiency virus (HIV), immune reconstitution inflammatory syndrome (IRIS), reactivation, Uganda
Abstract

Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P < .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.

PMCID

PMC4548459