TabMenu

Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Prevalence and determinants of elevated gamma-glutamyl transferase in Chinese hypertensive adults

TitlePrevalence and determinants of elevated gamma-glutamyl transferase in Chinese hypertensive adults
Publication TypeJournal Article
Year of Publication2017
AuthorsZhao, X, Qin, X, Zhang, Y, Li, J, Wang, B, Wang, X, Xu, X, Xu, X, Yang, X, Huo, Y
JournalInternational Journal of Clinical and Experimental Medicine
Volume10
Pagination1725-1732
Type of ArticleArticle
ISBN Number19405901 (ISSN)
KeywordsChinese hypertensive adults, Determinants, Elevated gamma-glutamyl transferase, Prevalence
Abstract

Objectives: This study aims to examine the prevalence and determinants of elevated gamma-glutamyl transferase (GGT) in Chinese hypertensive adults aged 45-75 years. Methods: A cross-sectional investigation was carried out in the rural area of Lianyungang, Jiangsu provinces, China. A total of 14206 adults with hypertension (5602 men, age 59.5 ± 7.6 years) from two counties were analyzed. Elevated GGT was defined as a GGT level ≥50 IU/L. Results: The prevalence of elevated GGT was 8.59% (2.8% in women and 17.6% in men). Median GGT level was 20.2 IU/L (17.6 IU/L in women and 26.4 IU/L in men). In multiple logistic-regression analyses, women had lower risk for elevated GGT than men (OR, 0.29; 95% CI, 0.24-0.36), abdominal obesity (waist circumference ≥90 cm; OR, 1.42; 95% CI, 1.20-1.67), obesity (body mass index ≥25 kg/m2; OR, 1.69; 95% CI, 1.44-1.98), current drinking (OR, 3.57; 95% CI, 3.04-4.21) were important independent risk factors for elevated GGT in both genders. Age and physical activity levels were inversely associated with elevated GGT. In sex-subgroup analyses, antihypertensive treatment (OR, 0.84; 95% CI, 0.72-0.98) and inland (OR, 0.79; 95% CI, 0.68-0.93) had lower risk and red meat consumption ≥3 times (OR, 1.47; 95% CI, 1.19-1.83) and elementary or higher levels (OR, 1.28; 95% CI, 1.06-1.55) had high risk for elevated GGT in men but not in women. Conclusions: There was a high prevalence of elevated GGT in Chinese hypertensive adults, a high prevalence of elevated GGT in male participants from coastal (vs. inland) areas. Physical activity is necessary to decrease GGT level. A detrimentally effect of current drinking, obesity or waist circumference on the GGT levels was also observed in both gender and a detrimentally effect of greater red meat consumption only in male was observed. © 2017, E-Century Publishing Corporation. All rights reserved.