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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

TitlePopulation-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico
Publication TypeJournal Article
Year of Publication2016
AuthorsRudolph, SE, Lorincz, A, Wheeler, CM, Gravitt, P, Lazcano-Ponce, E, Torres-Ibarra, L, León-Maldonado, L, Ramírez, P, Rivera, B, Hernández, R, Franco, EL, Cuzick, J, Méndez-Hernández, P, Salmerón, J, Wheeler, C, Lazcano, E, León, L, Méndez, P, Hernández, M, Wright, TC, Moscicki, AB, Flores, Y, Stoler, MH, Carmona, E, Schmeler, KM, Bishai, D, Hernández, P, Alvarez, D, Barrios, E, Mendiola, I, González, V
JournalBMC Infectious Diseases
Volume16
Type of ArticleArticle
ISBN Number14712334 (ISSN)
KeywordsAdult, age, article, cancer screening, comparative study, condom use, contraceptive behavior, disease association, early cancer diagnosis, Early Detection of Cancer, Female, Genetics, Genotype, HPV16/18, human, Human papillomavirus 16, Human papillomavirus 18, Human papillomavirus DNA testing, Human papillomavirus type 16, Human papillomavirus type 18, Human papillomavirus type 31, Human papillomavirus type 33, Human papillomavirus type 35, Human papillomavirus type 39, Human papillomavirus type 45, Human papillomavirus type 51, Human papillomavirus type 52, Human papillomavirus type 56, Human papillomavirus type 58, Human papillomavirus type 59, Human papillomavirus type 66, Human papillomavirus type 68, human tissue, Humans, infection risk, isolation and purification, Logistic Models, major clinical study, medical history, Mexico, Middle Aged, mixed infection, Papillomavirus Infections, population research, Prevalence, risk factor, Risk Factors, sexuality, sexually transmitted disease, single woman, smoking, statistical model, Tlaxcala (state), Uterine Cervical Neoplasms, uterine cervicitis, uterine cervix cancer, virology, virus detection, Wart virus, Women's Health
Abstract

Background: Cervical cancer remains an important cause of cancer mortality for Mexican women. HPV 16/18 typing may help to improve cervical cancer screening. Here we present the prevalence of high-risk human papillomavirus (hrHPV) including HPV16 and HPV18 from the FRIDA (Forwarding Research for Improved Detection and Access) population. Methods: Beginning in 2013, we recruited 30,829 women aged 30-64 in Tlaxcala, Mexico. Cervical samples were collected and tested for 14 hrHPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68). We used logistic regression to estimate odds ratios with 95 % confidence intervals for hrHPV infections according to putative risk factors. Results: Prevalence of infection with any of the 14 hrHPV types was 11.0 %. The age-specific prevalence of all hrHPV formed a U-shaped curve with a higher prevalence for women aged 30-39 and 50-64 than women aged 40-49. Across all age groups, 2.0 % of women were positive for HPV16 and/or HPV18 (HPV16/18), respectively. HPV16/18 prevalence also showed a U-shaped curve with increased prevalence estimates for women aged both 30-39 and 60-64. Both prevalence curves had a significant quadratic age coefficient. Infections with hrHPV were positively associated with an increased number of lifetime sexual partners, a history of sexually transmitted disease, being unmarried, use of hormonal contraception, having a history of smoking and reported condom use in the multivariate model. Conclusions: The FRIDA population has a bimodal distribution of both hrHPV and HPV16/18 positivity with higher prevalences at ages 30-39 and 60-64. These findings will help to evaluate triage algorithms based on HPV genotyping. Trial registration: The trial is registered with ClinicalTrials.gov, number NCT02510027. © 2016 The Author(s).