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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda

TitleMale circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda
Publication TypeJournal Article
Year of Publication2014
AuthorsTobian, AA, Gaydos, C, Gray, RH, Kigozi, G, Serwadda, D, Quinn, N, Grabowski, MK, Musoke, R, Ndyanabo, A, Nalugoda, F, Wawer, MJ, Quinn, TC
JournalSexually Transmitted Infections
Volume90
Pagination150-4
Date PublishedMar
ISBN Number1368-4973
Accession Number24259189
Keywords*Circumcision, Male, *Sexual Partners, Adolescent, Adult, circumcision, Epidemiology (Clinical), Female, HIV Infections/*epidemiology/prevention & control, Humans, Incidence, Male, Middle Aged, Molecular Diagnostic Techniques, Mycoplasma, Mycoplasma genitalium/*isolation & purification, Mycoplasma Infections/*epidemiology/microbiology/prevention & control, Poisson Distribution, Risk Factors, sexual behavior, Uganda/epidemiology, Vagina/*microbiology
Abstract

OBJECTIVE: Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. METHODS: HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. RESULTS: Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). CONCLUSIONS: Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.

PMCID

4018720