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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR

TitleIndividual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR
Publication TypeJournal Article
Year of Publication2017
AuthorsChen, FR, Stroud, CB, Vrshek-Schallhorn, S, Doane, LD, Granger, DA
JournalBiol Psychol
Volume129
Pagination8-15
Date PublishedJul 27
ISBN Number0301-0511
Accession Number28757071
Keywords5-httlpr, adolescence, Early adversity, Latent trait cortisol, Salivary cortisol
Abstract

The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age=12.39years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPRxearly adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning.