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| Title | Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Grabowski, MK, Kigozi, G, Gray, RH, Armour, B, Manucci, J, Serwadda, D, Redd, AD, Nalugoda, F, Patel, EU, Wawer, MJ, Quinn, TC, Tobian, AA |
| Journal | J Infect Dis |
| Volume | 212 |
| Pagination | 1613-7 |
| Date Published | Nov 15 |
| ISBN Number | 1537-6613 (Electronic)0022-1899 (Linking) |
| Accession Number | 25943201 |
| Keywords | *Circumcision, Male, *Virus Shedding, Adolescent, Adult, Disease Transmission, Infectious/prevention & control, Herpes Genitalis/epidemiology/*virology, herpes simplex virus type 2 (HSV-2), Herpesvirus 2, Human/*isolation & purification, HIV Infections/complications, human immunodeficiency virus (HIV), Humans, Male, male circumcision, penile viral shedding, Prevalence, Prospective Studies, Risk Assessment, Uganda, Viral Load, Wounds and Injuries/*virology, Young Adult |
| Abstract | A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use. |
| PMCID | PMC4621246 |