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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda

TitleHepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda
Publication TypeJournal Article
Year of Publication2018
AuthorsBoon, D, Redd, AD, Laeyendecker, O, Engle, RE, Nguyen, H, Ocama, P, Boaz, I, Ndyanabo, A, Kiggundu, V, Reynolds, SJ, Gray, RH, Wawer, MJ, Purcell, RH, Kirk, GD, Quinn, TC, Stabinski, L
JournalJ Infect Dis
Volume217
Pagination785-789
Date PublishedFeb 14
ISBN Number0022-1899
Accession Number29186448
Keywordshepatitis E virus, HEV seroprevalence, Rakai, Uganda, viral hepatitis
Abstract

A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.

PMCID

PMC5853830