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Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

TitleGenomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1
Publication TypeJournal Article
Year of Publication2017
AuthorsMartino, DJ, Ashley, S, Koplin, J, Ellis, J, Saffery, R, Dharmage, SC, Gurrin, L, Matheson, MC, Kalb, B, Marenholz, I, Beyer, K, Lee, YA, Hong, X, Wang, X, Vukcevic, D, Motyer, A, Leslie, S, Allen, KJ, Ferreira, MA
JournalClin Exp Allergy
Volume47
Pagination217-223
Date PublishedFeb
ISBN Number1365-2222 (Electronic)0954-7894 (Linking)
Accession Number27883235
Keywordsfood allergy, Genetics, Gwas, hypersensitivity, Peanut allergy
Abstract

BACKGROUND: Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS) has been published. OBJECTIVE: To identify genetic variants associated with challenge-proven peanut allergy. METHODS: We carried out a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-allergic infants (all ~ 1 year old). We tested a total of 3.8 million single nucleotide polymorphisms, as well as imputed HLA alleles and amino acids. Replication was assessed by de novo genotyping in a panel of additional 117 cases and 380 controls, and in silico testing in two independent GWAS cohorts. RESULTS: We identified 21 independent associations at P