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Differential loss of invariant natural killer T cells and FoxP3(+) regulatory T cells in HIV-1 subtype A and subtype D infections

TitleDifferential loss of invariant natural killer T cells and FoxP3(+) regulatory T cells in HIV-1 subtype A and subtype D infections
Publication TypeJournal Article
Year of Publication2013
AuthorsFlach, B, Naluyima, P, Blom, K, Gonzalez, VD, Eller, LA, Laeyendecker, O, Quinn, TC, Serwadda, D, Sewankambo, NK, Wawer, MJ, Gray, RH, Michael, NL, Wabwire-Mangen, F, Robb, ML, Eller, MA, Sandberg, JK
JournalJournal of Acquired Immune Deficiency Syndromes (1999)
Volume63
Pagination289-93
Date PublishedJul 1
ISBN Number1944-7884 (Electronic)1525-4135 (Linking)
Accession Number23403863
KeywordsAdaptive Immunity, Adolescent, Adult, Antigens, CD1d/biosynthesis, Antigens, CD4/metabolism, Female, Forkhead Transcription Factors/metabolism, HIV Infections/ immunology/ virology, HIV-1/ classification/ immunology, Humans, Interleukin-2/biosynthesis, Lymphocyte Activation, Male, Middle Aged, Natural Killer T-Cells/ immunology, Sexual and Reproductive Health, T-Lymphocytes, Regulatory/ immunology, Young Adult
Abstract

HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3(+) regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

PMCID

PMC3683089