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Differential associations of interleukin 6 and intestinal fatty acid-binding protein with progressive untreated HIV-1 infection in Rakai, Uganda

TitleDifferential associations of interleukin 6 and intestinal fatty acid-binding protein with progressive untreated HIV-1 infection in Rakai, Uganda
Publication TypeJournal Article
Year of Publication2016
AuthorsOlwenyi, OA, Naluyima, P, Cham, F, Quinn, TC, Serwadda, D, Sewankambo, NK, Gray, RH, Sandberg, JK, Michael, NL, Wabwire-Mangen, F, Robb, ML, Eller, MA
JournalJournal of Acquired Immune Deficiency Syndromes
Volume72
Pagination15-20
Type of ArticleArticle
ISBN Number15254135 (ISSN)
Keywordsacquired immune deficiency syndrome, Acquired Immunodeficiency Syndrome, Adult, AIDS, biological marker, biomarkers, C reactive protein, C-Reactive Protein, CD4+ T lymphocyte, CD4-Positive T-Lymphocytes, CD8+ T lymphocyte, CD8-Positive T-Lymphocytes, disease course, Disease Progression, fatty acid binding protein, Fatty Acid-Binding Proteins, Female, HIV-1, human, Human immunodeficiency virus 1, Humans, IFABP, IL-6, IL6 protein, human, immune activation, immunology, inflammation, interleukin 6, Interleukin-6, Lymphocyte Activation, Male, metabolism, Middle Aged, neopterin, pathology, physiology, tight junction, Tight Junctions, Uganda, Young Adult
Abstract

The significance of HIV-associated immune activation and microbial translocation in Sub-Saharan African population remains poorly defined. We assessed biomarkers of inflammation, microbial translocation, and cellular activation and found most factors elevated in Ugandan HIV-1 seroconverters compared with community-matched controls. In contrast to previous findings in Western cohorts, C-reactive protein, neopterin, and intestinal fatty acid binding protein were not elevated. Higher T-cell activation and IL-6 were associated with faster disease progression. Surprisingly, intestinal fatty acid binding protein, indicative of enterocyte turnover, was higher in slow than in fast progressors. These data suggest differential relationships among biomarkers of intestinal barrier integrity and innate immune activation between developed countries and Sub- Saharan Africa. © Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved.