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Developmental origins of infant stress reactivity profiles: A multi-system approach

TitleDevelopmental origins of infant stress reactivity profiles: A multi-system approach
Publication TypeJournal Article
Year of Publication2016
AuthorsRash, JA, Thomas, JC, Campbell, TS, Letourneau, N, Granger, DA, Giesbrecht, GF, Team, PONSA
JournalDev Psychobiol
Volume58
Pagination578-99
Date PublishedJul
ISBN Number1098-2302 (Electronic)0012-1630 (Linking)
Accession Number26956370
KeywordsFetal programming, psychological distress, respiratory sinus arrhythmia, Salivary alpha-amylase, Salivary cortisol, Stress reactivity
Abstract

BACKGROUND: This study tested the hypothesis that maternal physiological and psychological variables during pregnancy discriminate between theoretically informed infant stress reactivity profiles. METHODS: The sample comprised 254 women and their infants. Maternal mood, salivary cortisol, respiratory sinus arrhythmia (RSA), and salivary alpha-amylase (sAA) were assessed at 15 and 32 weeks gestational age. Infant salivary cortisol, RSA, and sAA reactivity were assessed in response to a structured laboratory frustration task at 6 months of age. Infant responses were used to classify them into stress reactivity profiles using three different classification schemes: hypothalamic-pituitary-adrenal (HPA)-axis, autonomic, and multi-system. Discriminant function analyses evaluated the prenatal variables that best discriminated infant reactivity profiles within each classification scheme. RESULTS: Maternal stress biomarkers, along with self-reported psychological distress during pregnancy, discriminated between infant stress reactivity profiles. CONCLUSIONS: These results suggest that maternal psychological and physiological states during pregnancy have broad effects on the development of the infant stress response systems. (c) 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 578-599, 2016.