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Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

TitleCurrent Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases
Publication TypeJournal Article
Year of Publication2017
AuthorsMcAllister, K, Mechanic, LE, Amos, C, Aschard, H, Blair, IA, Chatterjee, N, Conti, D, Gauderman, WJ, Hsu, L, Hutter, CM, Jankowska, MM, Kerr, J, Kraft, P, Montgomery, SB, Mukherjee, B, Papanicolaou, GJ, Patel, CJ, Ritchie, MD, Ritz, BR, Thomas, DC, Wei, P, Witte, JS
JournalAm J Epidemiol
Volume186
Pagination753-761
Date PublishedOct 01
ISBN Number0002-9262
Accession Number28978193
Keywords*Gene-Environment Interaction, Disease/*etiology/genetics, environmental exposure, gene-environment interaction, Genetic Predisposition to Disease, genome-wide association study, Genome-Wide Association Study/*methods, High-Throughput Nucleotide Sequencing, Humans, Software
Abstract

Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (GxEs) in large-scale studies of human populations. There are opportunities in this field, particularly with respect to the incorporation of -omics and next-generation sequencing data and continual improvement in measures of environmental exposures implicated in complex disease outcomes. In a workshop called "Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases," held October 17-18, 2014, by the National Institute of Environmental Health Sciences and the National Cancer Institute in conjunction with the annual American Society of Human Genetics meeting, participants explored new approaches and tools that have been developed in recent years for GxE discovery. This paper highlights current and critical issues and themes in GxE research that need additional consideration, including the improved data analytical methods, environmental exposure assessment, and incorporation of functional data and annotations.