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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

TitleCord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Publication TypeJournal Article
Year of Publication2018
AuthorsRaghavan, R, Fallin, MD, Hong, X, Wang, G, Ji, Y, Stuart, EA, Paige, D, Wang, X
JournalJ Autism Dev Disord
Date PublishedJul 24
ISBN Number0162-3257
Accession Number30043356
Keywordsadiponectin, Autism, cytokines, preterm birth
Abstract

Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.