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Poverty and InequalitySexual and Reproductive HealthFamily, Maternal & Child HealthMethodology

Adiposity trajectory and its associations with plasma adipokine levels in children and adolescents-A prospective cohort study

TitleAdiposity trajectory and its associations with plasma adipokine levels in children and adolescents-A prospective cohort study
Publication TypeJournal Article
Year of Publication2016
AuthorsLi, S, Liu, R, Arguelles, L, Wang, G, Zhang, J, Shen, X, Wang, X
JournalObesity (Silver Spring)
Volume24
Pagination408-16
Date PublishedFeb
ISBN Number1930-7381
Accession Number26704698
Abstract

OBJECTIVE: This study aimed to examine the associations of longitudinal adiposity measures with two adipokines, leptin and adiponectin, and their ratio in children and adolescents. METHODS: A total of 953 children and adolescents participated in a 6-year longitudinal study. Body mass index (BMI), percentage body fat (%BF), and fat mass index (FMI) were used to assess adiposity status. RESULTS: After adjusting for possible confounders, our regression models revealed that BMI, %BF, and FMI, in both the baseline and follow-up surveys were independently associated with a higher level of leptin and the leptin/adiponectin ratio at the follow-up survey, whereas the significant association with adiponectin only partly existed in adiposity measures at the follow-up visit. Moreover, the longitudinal change in adiposity measures was found to be a significant predictor for follow-up plasma adipokine levels. Compared with the low-->low group, the medium-->medium group, up-trend group, and high-->high group all showed a significantly increased level of leptin and leptin/adiponectin ratio. The up-trend group and high-->high group also had significantly decreased adiponectin levels. CONCLUSIONS: These findings highlight the importance of adiposity surveillance and the utility of adipokines as biomarkers for adverse metabolic consequences of childhood adiposity.

PMCID

Pmc4731239